Anti-Haptoglobin Antibody [HP/3835] (A277646)

Name: Anti-Haptoglobin Antibody [HP/3835]
Brand: Antibodies.com
SKU: A277646
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [HP/3835] antibody to Haptoglobin for IHC-P.

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$40 to United States

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4-6 Business Days

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Monospecific Antibody

Specifications

Name

Anti-Haptoglobin Antibody [HP/3835]

Description

Mouse monoclonal [HP/3835] antibody to Haptoglobin.

Specificity

Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes, thereby inhibiting its oxidative activity. During this process, Haptoglobin sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis, Haptoglobin consists of two a and two b chains, connected by disulfide bridges. In human, Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1, Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia, the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin, lung and kidney.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment, around amino acids 100-250, of human Haptoglobin. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

HP/3835

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Molecular Weight

15-18 kDa / 45 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Haptoglobin Antibody [HP/3835] - BSA and Azide free (A278234).

Synonyms

binding peptide, BP, haptoglobin alpha 1S beta, haptoglobin alpha 2FS beta, Haptoglobin alpha chain, haptoglobin alpha polypeptide, Haptoglobin alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, haptoglobin beta polypeptide, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HP2ALPHA2, HPA1S, HPT, HPT_HUMAN, MGC111141, Zonulin

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (4)

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Figure 1: Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] (A277646)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver tissue using Anti-Haptoglobin Antibody [HP/3835] at 2µg/ml.

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Figure 2: Immunohistochemistry - Anti-Haptoglobin Antibody [HP/3835] (A277646)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver tissue using Anti-Haptoglobin Antibody [HP/3835] at 2µg/ml.

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Figure 3: SDS-PAGE - Anti-Haptoglobin Antibody [HP/3835] (A277646)

SDS-PAGE analysis of Anti-Haptoglobin Antibody [HP/3835] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-Haptoglobin Antibody [HP/3835] (A277646)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Haptoglobin Antibody [HP/3835]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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