Anti-Haptoglobin Antibody [C08-1E10] (Biotin) (A279940)

Anti-Haptoglobin Antibody [C08-1E10] (Biotin)

Mouse monoclonal [C08-1E10] antibody to Haptoglobin (Biotin).

This antibody recognises haptoglobin, an alpha sialoglycoprotein. Synthesis of haptoglobin is induced by IL-6, IL-1 beta and TNF and it is produced as a pro-protein before it is cleaved in the endoplasmic reticulum by C1r-like protein, to generate the mature form. Haptoglobin is composed of two peptide chains referred to as the alpha and beta chains. It is largely expressed by hepatocytes, but is also expressed to a lesser extent in lung, skin and kidney tissues. A key role of haptoglobin is its hemoglobin binding capacity, which is utilized during hemolysis to prevent iron loss and subsequent kidney damage. The haptoglobin-hemoglobin complex is removed by the CD163 receptor expressed on the surface of monocytes and macrophages. Haptoglobin also plays roles in the innate and adaptive immune system and has anti-inflammatory activity such as inhibiting monocyte production of TNF, IL-11 and IL-12. The biotinylated Mouse anti Human haptoglobin antibody, clone C08-1E10 (MCA6235B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human haptoglobin antibody, clone E07-10E9 (MCA6234GA) as the capture antibody.

ELISA: 1 µg/ml

Human

Native haptoglobin purified from human plasma.

Mouse

Monoclonal

C08-1E10

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human haptoglobin antibody, clone C08-1E10, recognizes haptoglobin, an alpha sialoglycoprotein. Synthesis of haptoglobin is induced by IL-6, IL-1 beta and TNF and it is produced as a pro-protein before it is cleaved in the endoplasmic reticulum by C1r-like protein, to generate the mature form (Redmond et al. 2018). Haptoglobin is composed of two peptide chains referred to as the alpha and beta chains. It is largely expressed by hepatocytes, but is also expressed to a lesser extent in lung, skin and kidney tissues (Vanuytsel et al. 2013). A key role of haptoglobin is its hemoglobin binding capacity, which is utilized during hemolysis to prevent iron loss and subsequent kidney damage. The haptoglobin-hemoglobin complex is removed by the CD163 receptor expressed on the surface of monocytes and macrophages (Sadrzadeh & Bozorgmehr 2004). Haptoglobin also plays roles in the innate and adaptive immune system and has anti-inflammatory activity such as inhibiting monocyte production of TNF, IL-11 and IL-12 (Arredouani et al. 2005).The biotinylated Mouse anti Human haptoglobin antibody, clone C08-1E10 (MCA6235B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human haptoglobin antibody, clone E07-10E9 (MCA6234GA) as the capture antibody.

binding peptide, BP, haptoglobin alpha 1S beta, haptoglobin alpha 2FS beta, Haptoglobin alpha chain, haptoglobin alpha polypeptide, Haptoglobin alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, haptoglobin beta polypeptide, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HP2ALPHA2, HPA1S, HPT, HPT_HUMAN, MGC111141, Zonulin

This product is for research use only. It is not intended for diagnostic or therapeutic use.