Anti-GM-CSF Antibody [E01-1B6] (A280284)

Anti-GM-CSF Antibody [E01-1B6]

Mouse monoclonal [E01-1B6] antibody to GM-CSF.

This antibody recognises Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) also known as colony stimulating factor 2. GM-CSF is a cytokine and acts as a hematopoietic grown factor and immune modulator of various immune cells. It is produced by immune cells including T cells and macrophages as well as endothelial and fibroblast cells. GM-CSF has various functions such as roles in recruiting circulating neutrophils, monocytes and lymphocytes. It is also involved in the maturation and activation of neutrophils and macrophages to induce microbial activity and the production of cytokines. GM-CSF elicits these functions through signaling via its receptor GM-CSFR to activate NF-kappaB or STAT5 signaling pathways. The purified Mouse anti Human GM-CSF antibody, clone E01-1B6 (MCA6230GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human GM-CSF antibody, clone E04-5B11 (MCA6231B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human GM-CSF (Ala18-Glu144).

Mouse

Monoclonal

E01-1B6

IgG2a

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human GM-CSF antibody, clone E01-1B6, recognizes Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) also known as colony stimulating factor 2. GM-CSF is a cytokine and acts as a hematopoietic grown factor and immune modulator of various immune cells. It is produced by immune cells including T cells and macrophages as well as endothelial and fibroblast cells. GM-CSF has various functions such as roles in recruiting circulating neutrophils, monocytes and lymphocytes (Shi et al. 2006). It is also involved in the maturation and activation of neutrophils and macrophages to induce microbial activity and the production of cytokines. GM-CSF elicits these functions through signaling via its receptor GM-CSFR to activate NF-kappaB or STAT5 signaling pathways (Dougan et al. 2019).The purified Mouse anti Human GM-CSF antibody, clone E01-1B6 (MCA6230GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human GM-CSF antibody, clone E04-5B11 (MCA6231B) as the detection antibody.

Colony stimulating factor, Colony Stimulating Factor 2, Colony stimulating factor 2 (granulocyte-macrophage), Colony-stimulating factor, CSF, CSF 2, CSF2, CSF2_HUMAN, GMCSF, Granulocyte Macrophage Colony Stimulating Factor, Granulocyte-macrophage colony-stimulating factor, MGC131935, MGC138897, MGI1GM, Molgramostin, Pluripoietin-a, Sargramostim