Recombinant Anti-Glutamine Synthetase Antibody [rGLUL/8621] (A315027)

Anti-Glutamine Synthetase Antibody [rGLUL/8621]

Recombinant mouse monoclonal [rGLUL/8621] antibody to Glutamine Synthetase.

Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

Human brain, stomach or thyroid.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human GLUL protein. The exact sequence is proprietary.

Mouse

Monoclonal

rGLUL/8621

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

42 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

cell proliferation-inducing protein 59, GLNA, GLNA_HUMAN, GLNS, GLUL, Glutamate ammonia ligase, Glutamate decarboxylase, Glutamate--ammonia ligase, glutamine synthase, GS, PIG 43, PIG 59, PIG43, PIG59, Proliferation inducing protein 43