Anti-GCLM Antibody [GCLM/4069] - BSA and Azide free (A316390)

$765

Mouse monoclonal [GCLM/4069] antibody to GCLM for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-GCLM Antibody [GCLM/4069] - BSA and Azide free
Description
Mouse monoclonal [GCLM/4069] antibody to GCLM.
Specificity
g-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.
Applications
IHC-P
Positive Control
Human colon carcinoma (IHC).
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human GCLM protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
GCLM/4069
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
31 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Gamma ECS regulatory subunit, Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, GCS light chain, GLCLR, Glutamate cysteine ligase regulatory subunit, Glutamate--cysteine ligase modifier subunit, Glutamate--cysteine ligase regulatory subunit, GSC light chain, GSH0_HUMAN
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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