Anti-ZAP70 (phospho Tyr493) Antibody (A283686)

Anti-ZAP70 (phospho Tyr493) Antibody

Rabbit polyclonal antibody to ZAP70 (phospho Tyr493).

This antibody recognises ZAP 70, also known as Zeta-chain-associated protein kinase 70 when phosphorylated at tyrosine 493. ZAP70 is a member of the tyrosine kinase family. ZAP 70 plays a key role in the activation of T cells. ZAP 70 is phosphorylated at tyrosine 493 by Lck in response to T cell receptor stimulation. Phosphorylation of ZAP 70 at tyrosine 493 fully activates ZAP 70 leading to phosphorylation of downstream targets of the T cell activation pathway.

WB, IHC-P

IHC-P: 1:50 - 1:100, WB: 1:500 - 1:2,000

Human, Mouse, Rat

Phospho-specific peptide corresponding to residues surrounding Tyr493 of human ZAP 70.

Rabbit

Polyclonal

IgG

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti ZAP 70 (pTyr493) antibody recognizes ZAP 70, also known as Zeta-chain-associated protein kinase 70 when phosphorylated at tyrosine 493. ZAP70 is a member of the tyrosine kinase family. ZAP 70 plays a key role in the activation of T cells. ZAP 70 is phosphorylated at tyrosine 493 by Lck in response to T cell receptor stimulation (Wang et al. 2010). Phosphorylation of ZAP 70 at tyrosine 493 fully activates ZAP 70 leading to phosphorylation of downstream targets of the T cell activation pathway.