Recombinant Anti-ZAP70 Antibody [ZAP70/6492R] - BSA and Azide free (A278666)

Anti-ZAP70 Antibody [ZAP70/6492R] - BSA and Azide free

Recombinant rabbit monoclonal [ZAP70/6492R] antibody to ZAP70.

Zeta-associated protein-70 (ZAP-70) is a member of the Syk family of tyrosine kinases, a group of proteins that attach to the zeta chain components of T-cell receptors to signal downstream events involved in the regulation of cell function, proliferation, and death. Research suggests that the ZAP-70 protein may also play an important role in natural killer (NK) cell activation and early B-cell development; however, it is not expressed in most normal mature B-cells. Expression of ZAP-70 has been reported in various lymphomas, including mantle cell lymphoma, small lymphocytic lymphoma and marginal zone lymphoma. During thymocyte development, ZAP-70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP-70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).

ELISA, IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 247-382, of human ZAP70 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

ZAP70/6492R

Protein A/G chromatography.

1 mg/ml

70 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-ZAP70 Antibody [ZAP70/6492R] (A278078).