Recombinant Anti-Ubiquitin Anticorps [UBB/3143R] (A250263)

Anti-Ubiquitin Antibody [UBB/3143R]

Recombinant rabbit monoclonal [UBB/3143R] antibody to Ubiquitin.

Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimers disease etc.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 1-119, of human Ubiquitin protein. The exact sequence is proprietary.

Rabbit

Monoclonal

UBB/3143R

IgG

Protein A/G chromatography.

200 µg/ml

9 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Ubiquitin Antibody [UBB/3143R] - BSA and Azide free (A253443).

Epididymis secretory protein Li 50, FLJ25987, HEL S 50, MGC8385, Polyubiquitin B, RPS 27A, RPS27A, UBA 52, UBA 80, UBA52, UBA80, UBB, UBB_HUMAN, UBC, UBCEP 1, UBCEP 2, UBCEP1, UBCEP2, Ubiquitin B, UBIQ_HUMAN