Anti-TSH beta Anticorps [TSHb/1317] (A250217)

Anti-TSH beta Antibody [TSHb/1317]

Mouse monoclonal [TSHb/1317] antibody to TSH beta.

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH) follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment of human TSH beta protein.

Mouse

Monoclonal

TSHb/1317

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

16 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TSH beta Antibody [TSHb/1317] - BSA and Azide free (A253397).

CHNG4, Thyroid stimulating hormone beta subunit, Thyroid stimulating hormone, beta precursor, Thyrotropin beta subunit, TSHB