Anti-TRPC6 Anticorps [TRPC6/7671] (A315760)

Anti-TRPC6 Antibody [TRPC6/7671]

Mouse monoclonal [TRPC6/7671] antibody to TRPC6.

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

IHC-P

Human adrenal cortex, pancreas or brain.

IHC: 1-2 µg/ml

Human

Recombinant full-length human TRPC6 protein.

Mouse

Monoclonal

IgG2

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

50.9 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

bZ1P14.9, FLJ11098, FLJ14863, FSGS2, MTRP6, Short transient receptor potential channel 6, si:rp71-1p14.9, Transient receptor potential cation channel subfamily C member 6, Transient receptor protein 6, TRP 6, TRP-6, TRP6, TRPC 6, TRPC6_HUMAN, TRRP6