Anti-Tropomodulin 1 Anticorps [TRM-17 (Mab17)] (A281842)

Anti-Tropomodulin 1 Antibody [TRM-17 (Mab17)]

Mouse monoclonal [TRM-17 (Mab17)] antibody to Tropomodulin 1.

This antibody recognises chicken tropomodulin 1, otherwise known as erythrocyte tropomodulin or E-Tmod, an evolutionary very highly conserved cytoskeletal protein. Tropomodulin 1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton.recognises an epitope between amino acid residues 6-57 within the N-terminal region of tropomodulin 1 and inhibits the binding of Tmod1 to tropomyosin.

WB, ELISA, Functional Assays, IF

Chicken, Birds, Mammals, Fish, Insect, Reptile

Recombinant Chicken tropomodulin 1.

Mouse

Monoclonal

TRM-17 (Mab17)

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Approximately 40 kDa in chick heart lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Tropomodulin 1 (N-Terminal) antibody, clone TRM-17 recognizes chicken tropomodulin 1, otherwise known as erythrocyte tropomodulin or E-Tmod, an evolutionary very highly conserved cytoskeletal protein .Tropomodulin 1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton.Mouse anti Tropomodulin 1 (N-Terminal) antibody, clone TRM-17 recognizes an epitope between amino acid residues 6-57 within the N-terminal (NT) region of tropomodulin 1 and inhibits the binding of Tmod1 to tropomyosin.

D9S57E, E Tmod, E tropomodulin, E-Tmod, Erythrocyte tropomodulin, ETMOD, MGC124125, MGC124126, OTTHUMP00000021743, TMOD, Tmod1, TMOD1 protein, TMOD1_HUMAN, Tropomodulin-1