Anti-TrkC Anticorps [NTRK3/7140] (A317139)

$765

Anticorps monoclonal [NTRK3/7140] de souris contre TrkC pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-TrkC Antibody [NTRK3/7140] - BSA and Azide free
Description du produit
Mouse monoclonal [NTRK3/7140] antibody to TrkC.
Spécificité
The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.
Applications
IHC-P
Contrôle positif
Human nervous tissue.
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 100-300) of human NTRK3 protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
NTRK3/7140
Isotype
IgG1
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
50-145 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
EC 2.7.10.1, ETS related protein neurotrophic receptor tyrosine kinase fusion, ETS related protein neurotrophic receptor tyrosine kinase fusion protein, ETV6 NTRK3 fusion, GP145 TrkC, gp145(trkC), GP145-TrkC, GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, Neurotrophin 3 receptor, NT 3 growth factor receptor, NT 3 growth factor receptor precursor, NT 3 receptor, NT-3 growth factor receptor, Ntrk3, NTRK3_HUMAN, OTTHUMP00000192915, TRK C, Trk-C, TrkC tyrosine kinase, Tyrosine kinase receptor C
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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