Anti-TrkC Antibody [NTRK3/7140] (A315755)

Anti-TrkC Antibody [NTRK3/7140]

Mouse monoclonal [NTRK3/7140] antibody to TrkC.

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.

Human nervous tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 100-300) of human NTRK3 protein. The exact sequence is proprietary.

Mouse

Monoclonal

NTRK3/7140

kappa

Protein A/G chromatography.

200 µg/ml

50-145 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GP145-TrkC, Neurotrophic tyrosine kinase receptor type 3, NT-3 growth factor receptor, NTRK3, Trk-C, TrkC tyrosine kinase