The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.

Applications

IHC-P

Contrôle positif

Human nervous tissue.

Recommander des dilutions

IHC: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment (around Amino Acids 100-300) of human NTRK3 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

NTRK3/7140

Isotype

IgG1

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

50-145 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Synonymes

EC 2.7.10.1, ETS related protein neurotrophic receptor tyrosine kinase fusion, ETS related protein neurotrophic receptor tyrosine kinase fusion protein, ETV6 NTRK3 fusion, GP145 TrkC, gp145(trkC), GP145-TrkC, GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, Neurotrophin 3 receptor, NT 3 growth factor receptor, NT 3 growth factor receptor precursor, NT 3 receptor, NT-3 growth factor receptor, Ntrk3, NTRK3_HUMAN, OTTHUMP00000192915, TRK C, Trk-C, TrkC tyrosine kinase, Tyrosine kinase receptor C

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.