This antibody recognises p53DINP1 (p53-dependent damage-inducible nuclear protein 1). The protein promotes p53 phosphorylation on Ser46 in response to DNA double strand breaks, thereby inducing apoptosis. p53DINP1 is found in the nucleus and is ubiquitously expressed. Expression is dramatically reduced in pancreatic ductal adenocarcinomas early in the development of pancreatic cancer.Two isoforms of the protein exists, a 27kDa alpha and an 18kDa beta form. AHP1659 detects a band of 27kDa in human lung tissue lysate. In human spleen, and mouse liver and kidney tissue a band is detected at 18kDa.

Applications

WB, IHC-P

Recommander des dilutions

IHC-P 1: 2 µg/ml, WB: 1.0 - 2 µg/ml

Reactivité

Human, Mouse, Rat

Immunogène

A peptide corresponding to 14 amino acids near the N-terminus of human p53DINP1.

Hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Conjuguer

Unconjugated

Concentration

1 mg/ml

Forme du produit

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Rabbit anti p53DINP1 antibody recognizes p53DINP1 (p53-dependent damage-inducible nuclear protein 1). The protein promotes p53 phosphorylation on Ser46 in response to DNA double strand breaks, thereby inducing apoptosis. p53DINP1 is found in the nucleus and is ubiquitously expressed. Expression is dramatically reduced in pancreatic ductal adenocarcinomas early in the development of pancreatic cancer.Two isoforms of the protein exists, a 27kDa alpha and an 18kDa beta form. AHP1659 detects a band of 27kDa in human lung tissue lysate. In human spleen, and mouse liver and kidney tissue a band is detected at 18kDa.

Synonymes

DKFZp434M1317, FLJ22139, p53 damage inducible nuclear protein 1, p53 dependent damage inducible nuclear protein 1, p53 DINP1, p53 inducible nuclear protein 1, p53 inducible p53DINP1, p53-dependent damage-inducible nuclear protein 1, p53DINP1, SIP, Stress induced protein, Stress-induced protein, T53I1_HUMAN, Teap, TP53 DINP1, TP53 INP1, TP53DINP1, TP53INP1A, TP53INP1B, Tumor protein p53 inducible nuclear protein 1, Tumor protein p53-inducible nuclear protein 1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.