Recombinant rabbit monoclonal [TIMP2/8193R] antibody to TIMP2.
Specificity
It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Applications
IHC-P
Positive Control
Normal Placenta, Prostate or Ovarian Carcinoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment of human TIMP2 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
TIMP2/8193R
Isotype
IgG
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
21 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
CSC-21K, Metalloproteinase inhibitor 2, TIMP-2, Tissue inhibitor of metalloproteinases 2
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