Anti-TIGIT Anticorps [TIGIT/3017] (A248428)

Anticorps monoclonal [TIGIT/3017] de souris contre TIGIT pour ELISA, Flow Cytometry et IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-TIGIT Antibody [TIGIT/3017]
Description du produit
Mouse monoclonal [TIGIT/3017] antibody to TIGIT.
Spécificité
TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Applications
ELISA, Flow Cytometry, IHC-P
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment, around amino acids 22-141, of human TIGIT protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
TIGIT/3017
Isotype
IgG2c
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
26 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TIGIT Antibody [TIGIT/3017] - BSA and Azide free (A251610).
Synonymes
DKFZp667A205, ENSMUSG00000071552, FLJ39873, RGD1563191, T cell immunoreceptor with Ig and ITIM domains, TIGIT_HUMAN, V-set and immunoglobulin domain containing 9, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain containing 3, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3, Washington University cell adhesion molecule, WUCAM
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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