Anti-TIA1 Antibody [TIA1/1313] (A250129)

Anti-TIA1 Antibody [TIA1/1313]

Mouse monoclonal [TIA1/1313] antibody to TIA1.

TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.

Flow Cytometry, IF, WB

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 279-380, of human TIA1 protein.

Mouse

Monoclonal

TIA1/1313

IgG2b

Protein A chromatography.

200 µg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TIA1 Antibody [TIA1/1313] - BSA and Azide free (A253309).

Cytotoxic granule associated RNA binding protein TIA1, Nucleolysin TIA-1 isoform p40, p40-TIA-1, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1