Anti-Thyroid Peroxidase Anticorps [TPO/1921] (A250199)

Anti-Thyroid Peroxidase Antibody [TPO/1921]

Mouse monoclonal [TPO/1921] antibody to Thyroid Peroxidase.

Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 685-804, of human TPO protein. The exact sequence is proprietary.

Mouse

Monoclonal

TPO/1921

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

100 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Thyroid Peroxidase Antibody [TPO/1921] - BSA and Azide free (A253379).

MSA, PERT_HUMAN, TDH2A, Thyroid microsomal antigen, Thyroperoxidase, TPO, TPX