Recombinant Anti-Thymidine Phosphorylase Anticorps [TYMP/2890R] (A248385)

Anticorps monoclonal [TYMP/2890R] de lapin contre Thymidine Phosphorylase pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Thymidine Phosphorylase Antibody [TYMP/2890R]
Description du produit
Recombinant rabbit monoclonal [TYMP/2890R] antibody to Thymidine Phosphorylase.
Spécificité
This antibody recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Applications
IHC-P
Recommander des dilutions
IHC-P: 1-2 µg/ml
Reactivité
Human, Mouse, Rat
Immunogène
Recombinant full-length human Thymidine Phosphorylase protein.
Hôte
Rabbit
Clonalité
Monoclonal
Clone
TYMP/2890R
Isotype
IgG
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
55 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] - BSA and Azide free (A251567).
Synonymes
ECGF, ECGF 1, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Endothelial cell growth factor, platelet-derived, Gliostatin, hPD ECGF, MEDPS1, MNGIE, MTDPS1, PD ECGF, PD-ECGF, PDECGF, PDEGF, Platelet derived endothelial cell growth factor, Platelet derived endothelial growth factor, Platelet-derived endothelial cell growth factor, TdRPase, TP, Tymp, TYPH_HUMAN
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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