Recombinant Anti-TdT Anticorps [DNTT/4617R] (A277973)

Anti-TdT Antibody [DNTT/4617R]

Recombinant rabbit monoclonal [DNTT/4617R] antibody to TdT.

Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 52-192, of human TdT protein. The exact sequence is proprietary.

Rabbit

Monoclonal

DNTT/4617R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TdT Antibody [DNTT/4617R] - BSA and Azide free (A278561).

Deoxynucleotidyltransferase terminal, DNA nucleotidylexotransferase, DNTT, Nucleosidetriphosphate DNA deoxynucleotidylexotransferase, TDT_HUMAN, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal deoxyribonucleotidyltransferase, Terminal transferase