Anti-TCF7 Anticorps [TCF7/7631] (A315713)

Anti-TCF7 Antibody [TCF7/7631]

Mouse monoclonal [TCF7/7631] antibody to TCF7.

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5) found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

IHC-P

Human spleen, lung, adrenal gland or colon.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human TCF7 protein. The exact sequence is proprietary.

Mouse

Monoclonal

TCF7/7631

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

41.6 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

FLJ36364, MGC47735, OTTHUMP00000159391, T cell factor 1, T cell specific transcription factor 1, T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF1, TCF7 transcription factor 7, TCF7_HUMAN, Transcription factor 7, Transcription factor 7 (T cell specific HMG box), Transcription factor-7, T-cell specific, Transcription factor-7, T-cell specific, 1