Anti-STAT6 Anticorps [STAT6/2410] (A250067)

Name: Anti-STAT6 Antibody [STAT6/2410]
Brand: Antibodies.com
SKU: A250067
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [STAT6/2410] de souris contre STAT6 pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-STAT6 Antibody [STAT6/2410]

Description du produit

Mouse monoclonal [STAT6/2410] antibody to STAT6.

Spécificité

STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant full-length human STAT6 protein.

Hôte

Mouse

Clonalité

Monoclonal

Clone

STAT6/2410

Isotype

IgG1

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

119 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-STAT6 Antibody [STAT6/2410] - BSA and Azide free (A253247).

Synonymes

12S1644, D12S1644, IL 4 STAT, IL-4 Stat, IL4 STAT, Interleukin 4 Induced, Interleukin 4 Induced Transcription Factor IL4 STAT, Signal transducer and activator of transcription 6, Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced, Signal Transducer And Activator Of Transcription 6 Nirs Variant 1, Signal transducer and activator of transcription 6, interleukin 4 induced, STAT 6, STAT interleukin4 induced, STAT, interleukin4 induced, STAT6B, STAT6C, STAT6_HUMAN, Transcription factor IL 4 STAT

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Immunohistochemistry - Anti-STAT6 Antibody [STAT6/2410] (A250067)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinoma using Anti-STAT6 Antibody [STAT6/2410].

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Figure 2: SDS-PAGE - Anti-STAT6 Antibody [STAT6/2410] (A250067)

SDS-PAGE analysis of Anti-STAT6 Antibody [STAT6/2410] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 3: Anti-STAT6 Antibody [STAT6/2410] (A250067)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-STAT6 Antibody [STAT6/2410]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.