Anti-STAT5A Anticorps [PCRP-STAT5A-1A11] (A253243)

Name: Anti-STAT5A Antibody [PCRP-STAT5A-1A11] - BSA and Azide free
Brand: Antibodies.com
SKU: A253243
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [PCRP-STAT5A-1A11] de souris contre STAT5A pour Flow Cytometry.

Qualité 100 % Garantie

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-STAT5A Antibody [PCRP-STAT5A-1A11] - BSA and Azide free

Description du produit

Mouse monoclonal [PCRP-STAT5A-1A11] antibody to STAT5A.

Spécificité

Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4- mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Applications

Flow Cytometry

Recommander des dilutions

Flow Cytometry: 1-2 µg/million cells

Reactivité

Human

Réactivité croisée

This antibody is predicted to cross react with Mouse and Rat.

Immunogène

STAT5A protein domain.

Hôte

Mouse

Clonalité

Monoclonal

Clone

PCRP-STAT5A-1A11

Isotype

IgG1

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Masse moléculaire

92 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-STAT5A Antibody [PCRP-STAT5A-1A11] (A250063).

Synonymes

Mammary gland factor, MGF, Signal transducer and activator of transcription 5A, STA5A_HUMAN, STAT 5, STAT 5A, STAT5

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Flow Cytometry - Anti-STAT5A Antibody [PCRP-STAT5A-1A11] - BSA and Azide free (A253243)

Flow cytometric analysis of PFA fixed HeLa cells using Anti-STAT5A Antibody [PCRP-STAT5A-1A11] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).

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Figure 2: Anti-STAT5A Antibody [PCRP-STAT5A-1A11] - BSA and Azide free (A253243)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-STAT5A Antibody [PCRP-STAT5A-1A11]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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Figure 3: SDS-PAGE - Anti-STAT5A Antibody [PCRP-STAT5A-1A11] - BSA and Azide free (A253243)

SDS-PAGE analysis of Anti-STAT5A Antibody [PCRP-STAT5A-1A11] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.