Anti-SMNDC1 Anticorps [PCRP-SMNDC1-1A9] (A248099)

Anticorps monoclonal [PCRP-SMNDC1-1A9] de souris contre SMNDC1 pour Flow Cytometry et IF.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-SMNDC1 Antibody [PCRP-SMNDC1-1A9]
Description du produit
Mouse monoclonal [PCRP-SMNDC1-1A9] antibody to SMNDC1.
Spécificité
SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
Applications
Flow Cytometry, IF
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human SMNDC1 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-SMNDC1-1A9
Isotype
IgG2b
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
30 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SMNDC1 Antibody [PCRP-SMNDC1-1A9] - BSA and Azide free (A251282).
Synonymes
30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMN-related protein, SMNR, SPF30, SPF30_HUMAN, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing 1, Survival motor neuron domain containing protein 1, Survival motor neuron domain-containing protein 1, Survival of motor neuron related splicing factor 30, Survival of motor neuron-related-splicing factor 30
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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