Anti-SHP1 Anticorps [PTPN6/7543] (A317021)

$765

Anticorps monoclonal [PTPN6/7543] de souris contre SHP1 pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-SHP1 Antibody [PTPN6/7543] - BSA and Azide free
Description du produit
Mouse monoclonal [PTPN6/7543] antibody to SHP1.
Spécificité
PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).
Applications
IHC-P
Contrôle positif
Human tonsil, lymph node or spleen.
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 395-595) of human PTPN6 protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PTPN6/7543
Isotype
IgG1
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
65 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
70Z-SHP, EC 3.1.3.48, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, Protein-tyrosine phosphatase 1C, protein-tyrosine phosphatase SHP 1, Protein-tyrosine phosphatase SHP-1, PTN6_HUMAN, PTP 1C, PTP-1C, PTP1C, Ptpn6, SH PTP 1, SH PTP1, SH-PTP1, SHP 1, SHP 1L, SHP1L, tyrosine protein phosphatase non receptor type 6, Tyrosine-protein phosphatase non-receptor type 6
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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