Oligodendrocytes are glial cells found within the brain and spinal cord. They are responsible for providing myelin sheath to neuronal axons within the central nervous system, similar to the function of Schwann cells within the peripheral nervous system, and for providing metabolic support. One oligodendrocyte can insulate up to fifty neuronal axons.
Insulating-myelin sheaths are essential for fast action potential conduction along the neuronal axon which ensures effective neuronal function. The insulating-myelin sheath is approximately eighty percent lipid and twenty percent protein and is comprised of sphingomyelin, cholesterol, glycolipids, and proteins such as myelin basic protein and myelin oligodendrocyte glycoprotein.
Oligodendrocytes also provide trophic support to neurons; producing glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and insulin-like growth factor-1 (IGF-1).
With such a versatile role, loss of oligodendrocytes or damage to these cells can impact the effectiveness of CNS function, increasing oxidative stress, and result in irreversible neuronal damage, as characterized in conditions such as multiple sclerosis.
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Target information from UniProt accession P02686.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-MBP Antibody [7G7] (A85322) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Anti-MBP Antibody [7D2] (A85329) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Anti-MBP Antibody (A85321) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Recombinant Anti-Myelin Basic Protein Antibody [MBP/4277R] (A249285) | Human | IHC-P |
| Recombinant Anti-Myelin Basic Protein Antibody [rMBP/4288] (A249284) | Human | WB, IHC-P |
| Anti-Myelin Basic Protein Antibody [ABT-MBP] (A95520) | Human | IHC |
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. Target information from NCBI Gene ID: 4340.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-MOG Antibody (A83178) | Human | ELISA, WB, IHC |
| Anti-MOG Antibody (A35668) | Human, Mouse, Rat | WB, IHC, IF |
| Anti-MOG Antibody [NYRMOG] (A58444) | Wide species range | ELISA, WB, IP, IHC |
Olig1 is a bHLH transcription factor expressed exclusively in oligodendrocytes after late embryonic development. It is thought to be a necessary factor for oligodendrocyte progenitor cell commitment to an oligodendrocyte fate, along with the related factor Olig2. Olig1-null mice brains show impaired oligodendrocyte differentiation, though compensatory increased Olig2 expression may decrease the phenotype severity. Target information from Dai et al., 2015..
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-OLIG1 Antibody (A42684) | Human | WB |
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Target information from UniProt accession Q13516.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-OLIG2 Antibody [OLIG2/2400] (A248077) | Human | IHC-P |
| Anti-Olig2 Antibody (A54718) | Human, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-Olig2 Antibody (A54719) | Human, Mouse, Rat | ELISA, IMM, WB |
| Anti-Olig2 Antibody (Biotin) (A52988) | Human, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-Olig2 Antibody (FITC) (A53885) | Human, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-Olig2 Antibody (FITC) (A53111) | Human, Mouse, Rat | ELISA, IMM, WB |
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. Target information from NCBI Gene ID: 6663.
| Product Name | Reactivity | Applications |
|---|---|---|
| Recombinant Anti-SOX10 Antibody [SOX10/2311R] (A250019) | Human, Mouse | WB, IHC-P |
| Recombinant Anti-SOX10 Antibody [rSOX10/1074] (A250017) | Human, Mouse | WB, IHC-P |
| Anti-SOX10 Antibody [SOX10/991] (A250013) | Human, Mouse | WB, IHC-P |
| Anti-SOX10 Antibody (A54775) | Human, Monkey | ELISA, IHC, IP, WB |
| Anti-SOX10 Antibody (FITC) (A53138) | Human, Monkey | ELISA, IHC, IP, WB |
| Anti-SOX10 Antibody (Biotin) (A52341) | Human, Monkey | ELISA, IHC, IP, WB |
CNPase (2',3'-cyclic nucleotide-3'-phosphodiesterase) is a ubiquitous protein that is highly elevated within central nervous system myelin, making up 4% of the myelin protein content. It is also expressed earlier than any other myelin protein. Although the molecule is able to catalyse the cleavage of 2′,3′-cyclic nucleotides to 2′-nucleotides, the purpose of this reaction within the myelin sheath is not understood, and may even be an evolutionarily redundant function. Suggested roles for CNPase include polymerization of microtubules and actin cytoskeleton components, leading to cell morphological changes and oligodendrocyte membrane outgrowth. CNPase is also shown to bind RNA, and may have a role as a tRNA editor and protein synthesis suppressor. CNPase’s complete functional purpose may even be the intersection of these two theories, in linking the transcriptional machinery to cytoskeletal components. An isoform of CNPase, CNP2, is also expressed in the mitochondria at low levels in many non-neuronal tissues, though its function is unknown. Target information from Fulton et al., 2010..
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-CNPase Antibody [1H10] (A85413) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-CNPase Antibody (A85409) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-CNPase Antibody (A85412) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-CNPase (A108) Antibody (A26894) | Human, Mouse, Rat | WB, IHC |
| Anti-CNPase Antibody (A95632) | Human, Mouse, Rat | WB, IHC, ELISA |
| Anti-CNPase Antibody (A42049) | Human, Mouse, Rat | WB |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. Target information from NCBI Gene ID: 5010.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Claudin-11 Antibody (A30230) | Human, Mouse, Rat | WB, IHC, IF |
| Anti-Claudin-11 (S198) Antibody (A25094) | Human, Mouse, Rat | WB |
| Anti-Claudin 11 Antibody (A95712) | Human, Mouse, Rat | WB, ELISA |
| Anti-CLDN11 Antibody (A34987) | Human, Mouse, Rat | WB, IHC, IF |
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