During embryonic development, neuroepithelial cells function as neural stem cells (NSCs) and symmetrically divide to form the neural plate, which in turn undergoes folding to form the neural tube. In the developing nervous system, NSC's are highly polarised and maintain an apical domain facing a central lumen containing cerebrospinal fluid.
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). Target information from UniProt accession P48431.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-SOX2 Antibody (A24853) | Human, Mouse, Rat | WB |
| Anti-SOX2 Antibody (Biotin) (A52641) | Human, Monkey, Mouse, Pig | ELISA, IP, WB |
| Anti-SOX2 Antibody (FITC) (A53538) | Human, Monkey, Mouse, Pig | ELISA, IP, WB |
| Anti-SOX2 Antibody [SOX2/1791] (A250002) | Human, Mouse | ELISA, WB, IHC-P |
| Anti-SOX2 Antibody [SOX2/3169R] (A250006) | Human, Mouse | ELISA, WB, IHC-P |
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Target information from UniProt accession P48681.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Nestin Antibody (A440) | Mouse, Rat | WB, ICC, IHC |
| Anti-Nestin Antibody (A104326) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-Nestin Antibody (A85294) | Human | WB, ICC/IF |
| Anti-Nestin Antibody [4D11] (A85293) | Human, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-Nestin Antibody [NES/2911] (A248153) | Human | IHC-P |
| Anti-Nestin Antibody [7A3] (A439) | Mouse | ICC/IF, IHC |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. Target information from NCBI Gene ID: 4851.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Notch1 Antibody (A37268) | Human | WB, IHC |
| Anti-Notch 1 Antibody [mN1A] (A86356) | Human, Mouse | FC, IP, WB, IHC-Fr, ICC |
| Anti-Notch 1 Antibody [mN1A] (PE) (A86360) | Human, Mouse | FC, IP, WB, IHC-Fr, ICC |
| Anti-Notch 1 Antibody [mN1A] (A86354) | Human, Mouse | FC, IP, WB, IHC-Fr, ICC |
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. Target information from NCBI Gene ID: 3280.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-HES1 Antibody (A47158) | Human | IHC |
| Anti-HES1 Antibody (A43945) | Human | WB |
| Anti-HES1 Antibody (A49585) | Human, Mouse, Rat | ELISA, WB |
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. Target information from NCBI Gene ID: 100506658.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Occludin Antibody (A48424) | Human, Mouse, Rat | WB, IHC |
| Anti-Occludin Antibody (A38682) | Human | WB, IHC |
| Anti-Occludin Antibody (A25003) | Human, Mouse, Rat | IHC |
| Anti-Occludin Antibody [OCLN/2181] (A248063) | Human | WB, IHC-P |
| Anti-Occludin Antibody [OCLN/2183] (A248064) | Human | IHC-P |
| Anti-Occludin (A23) Antibody (A24989) | Human, Mouse, Rat | WB |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. Target information from UniProt accession P12830.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-E-Cadherin Antibody (A83532) | Human, Mouse, Rat, Porcine | ELISA, WB, IHC |
| Anti-E-Cadherin Antibody [67A4] (A86102) | Human | FC, IP, WB, IHC-Fr, ICC |
| Anti-E-Cadherin Antibody [67A4] (FITC) (A86099) | Human | FC, IP, WB, IHC-Fr, ICC |
| Anti-E-Cadherin Antibody [CDH1/1525] (A250825) | Human | FC, IF, WB, IHC-P |
| Anti-E-Cadherin Antibody [CDH1/2208R] (A250830) | Human | FC, IF, WB, IHC-P |
Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Target information from UniProt accession P56693.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-SOX10 Antibody (A54775) | Human, Monkey | ELISA, IHC, IP, WB |
| Anti-SOX10 Antibody (Biotin) (A52340) | Human, Monkey | ELISA, IP, WB |
| Anti-SOX10 Antibody (FITC) (A53138) | Human, Monkey | ELISA, IHC, IP, WB |
| Anti-SOX10 Antibody [SOX10/991] (A250013) | Human, Mouse | WB, IHC-P |
| Anti-SOX10 Antibody [SOX10/2311R] (A250019) | Human, Mouse | WB, IHC-P |
| Anti-SOX10 Antibody [PCRP-SOX10-1D8] (A250018) | Human | IHC-P |
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