Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

Applications

ELISA

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 34-235, of human RNLS protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

RNLS/1940

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

38 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Renalase Antibody [RNLS/1940] - BSA and Azide free (A252887).

Synonymes

6530404N21Rik, AI452315, AW060440, C10orf59, Chromosome 10 open reading frame 59, FLJ11218, HGNC:25641, Hypothetical protein LOC55328, MAO C, MAO-C, mMAO C, Monoamine oxidase C, Monoamine oxidase-C, Renalase FAD dependent amine oxidase, RNLS, RNLS_HUMAN

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.