Anti-Reelin Anticorps [RELN/4498] (A278170)

Anti-Reelin Antibody [RELN/4498] - BSA and Azide free

Mouse monoclonal [RELN/4498] antibody to Reelin.

Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

ELISA, IP, IF, WB, IHC-P

IP: 1-2µg / 100-500µg proteins, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse, Rat

Recombinant fragment, around amino acids 1,796-2,115, of human Reelin protein. The exact sequence is proprietary.

Mouse

Monoclonal

RELN/4498

IgG2b

Protein A/G chromatography.

1 mg/ml

387.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Reelin Antibody [RELN/4498] (A277582).

LIS2, PRO1598, Reeler, RELN, RELN_HUMAN, RL