Anti-PUMA Anticorps (A283911)

$420

Anticorps polyclonal de lapin contre PUMA pour WB et IHC-P.

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-PUMA Antibody
Description du produit
Rabbit polyclonal antibody to PUMA.
Spécificité
This antibody recognises the p53 - upregulated modulator of apoptosis, also known as Bcl-2 binding component 3, JFY-1 or Bcl-2. PUMA is a 193 amino acid ~20 kDa pro-apoptotic member of the BCL-2 family.Bcl-2 binding component 3 is localized to the mitochondria, binds BCL-2 and induces cytochrome C release and apoptosis in response to p53. Four isoforms of PUMA have been described due to alternative splicing. Rabbit anti PUMA antibody is expected to recognize the canonical isoform 1, also known as PUMA alpha, it is not expected to recognize any of the other isoforms of PUMA.
Applications
WB, IHC-P
Recommander des dilutions
IHC-P 1: 10 µg/ml, WB: 2 µg/ml - 4 µg/ml
Reactivité
Human, Mouse
Immunogène
Synthetic peptide sequence ARARQEGSSPEPVEG corresponding to the N-terminus of human Bcl-2 binding component 3.
Séquence
ARARQEGSSPEPVEG
Hôte
Rabbit
Clonalité
Polyclonal
Isotype
IgG
Conjuguer

Unconjugated

Concentration
1 mg/ml
Masse moléculaire
Approximately 23 kDa in K562 cell lysates.
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Rabbit anti PUMA antibody recognizes the p53 - upregulated modulator of apoptosis, also known as Bcl-2 binding component 3, JFY-1 or Bcl-2. PUMA is a 193 amino acid ~20 kDa pro-apoptotic member of the BCL-2 family.Bcl-2 binding component 3 is localized to the mitochondria, binds BCL-2 and induces cytochrome C release and apoptosis in response to p53 (Follis et al. 2013). Four isoforms of PUMA have been described due to alternative splicing. Rabbit anti PUMA antibody is expected to recognize the canonical isoform 1, also known as PUMA alpha, it is not expected to recognize any of the other isoforms of PUMA.
Synonymes
BBC 3, Bbc3, BBC3_HUMAN, BCL 2 binding component 3, Bcl-2-binding component 3, BCL2 binding component 3, JFY 1, JFY-1, JFY1, p53 up regulated modulator of apoptosis, p53 up-regulated modulator of apoptosis, p53 Upregulated Modulator of Apoptosis, PUMA alpha, PUMA/JFY1
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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