TARC est un gène codé par le symbole CCL17. Il est également connu sous le nom de: C-C motif chemokine 17; CC chemokine Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17. TARC a une masse de 10.51kDa et une longueur d'acide aminé de 94.
Nous proposons 3 TARC protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Résumé Entrez
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Spécificité tissulaire
Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Localisation cellulaire
Secreted.
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