PF4 est un gène codé par le symbole PF4. Communément appelé aussi: Platelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; CXCL4; SCYB4. PF4 a une masse de 10.85kDa et une longueur d'acide aminé de 101.
Nous proposons 8 PF4 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Résumé Entrez
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum.
Similitudes de séquence
Belongs to the intercrine alpha (chemokine CxC) family.
Localisation cellulaire
Secreted.
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