Periostin est un gène codé par le symbole POSTN. Communément appelé aussi: PN; Osteoblast-specific factor 2; OSF-2; POSTN; OSF2. Periostin a une masse de 93.31kDa et une longueur d'acide aminé de 836.
Nous proposons 3 Periostin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Résumé Entrez
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécificité tissulaire
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Modification post-traductionnelle
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).
Localisation cellulaire
Golgi apparatus. Secreted. Secreted > Extracellular space > Extracellular matrix.
Colocalizes with BMP1 in the Golgi.
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