Interferon gamma est un gène codé par le symbole IFNG. Communément appelé aussi: IFN-gamma; Immune interferon; IFNG. Interferon gamma a une masse de 19.35kDa, une longueur d'acide aminé de 166, et est impliqué dans Aplastic anemia.
Nous proposons 13 Interferon gamma protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Résumé Entrez
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.
Spécificité tissulaire
Released primarily from activated T lymphocytes.
Implication dans la maladie
Aplastic anemia: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
Similitudes de séquence
Belongs to the type II (or gamma) interferon family.
Modification post-traductionnelle
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Localisation cellulaire
Secreted.
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