IL2 est un gène codé par le symbole IL2. Communément appelé aussi: Interleukin-2; IL-2; T-cell growth factor; TCGF. IL2 a une masse de 17.63kDa et une longueur d'acide aminé de 153.
Nous proposons 14 IL2 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Résumé Entrez
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Similitudes de séquence
Belongs to the IL-2 family.
Localisation cellulaire
Secreted.
Liens de base de données
