IL13 est un gène codé par le symbole IL13. Communément appelé aussi: Interleukin-13; IL-13; NC30. IL13 a une masse de 15.82kDa, une longueur d'acide aminé de 146, et est impliqué dans Allergic rhinitis.
Nous proposons 11 IL13 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
Résumé Entrez
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Implication dans la maladie
Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Similitudes de séquence
Belongs to the IL-4/IL-13 family.
Localisation cellulaire
Secreted.
Liens de base de données
