HDGF est un gène codé par le symbole HDGF. Communément appelé aussi: Hepatoma-derived growth factor; High mobility group protein 1-like 2; HMG-1L2; HMG1L2. HDGF a une masse de 26.79kDa et une longueur d'acide aminé de 240.
Nous proposons 1 HDGF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
Résumé Entrez
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Spécificité tissulaire
Ubiquitous.
Similitudes de séquence
Belongs to the HDGF family.
Modification post-traductionnelle
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Localisation cellulaire
Nucleus. Cytoplasm. Secreted > Extracellular exosome.
Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
Liens de base de données
