Guanylate kinase est un gène codé par le symbole GUK1. Communément appelé aussi: GMP kinase 1; GUK1; GMK; GMPK. Guanylate kinase a une masse de 21.73kDa et une longueur d'acide aminé de 197.
Nous proposons 2 Guanylate kinase protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).
Résumé Entrez
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed.
Similitudes de séquence
Belongs to the guanylate kinase family.
Localisation cellulaire
Photoreceptor inner segment. Cytoplasm > Cytosol.
Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer.
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