Gastrin est un gène codé par le symbole GAST. Communément appelé aussi: GAST; GAS. Gastrin a une masse de 11.39kDa et une longueur d'acide aminé de 101.
Nous proposons 3 Gastrin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Résumé Entrez
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.
Similitudes de séquence
Belongs to the gastrin/cholecystokinin family.
Modification post-traductionnelle
Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Localisation cellulaire
Secreted.
Liens de base de données
