Follistatin est un gène codé par le symbole FST. D'autres noms incluent: FS; Activin-binding protein; FST. Follistatin a une masse de 38.01kDa et une longueur d'acide aminé de 344.
Nous proposons 4 Follistatin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Résumé Entrez
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Spécificité tissulaire
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
Localisation cellulaire
Secreted.
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