Cyclophilin A est un gène codé par le symbole PPIA. D'autres noms incluent: Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclosporin A-binding protein; Rotamase A; PPIA; CYPA. Cyclophilin A a une masse de 18.01kDa et une longueur d'acide aminé de 165.
Nous proposons 4 Cyclophilin A protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Résumé Entrez
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
Similitudes de séquence
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Modification post-traductionnelle
Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
Localisation cellulaire
Cytoplasm. Secreted.
Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
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