CXCL14 est un gène codé par le symbole CXCL14. D'autres noms incluent: C-X-C motif chemokine 14; Chemokine BRAK; MIP-2G; Small-inducible cytokine B14; MIP2G; NJAC; SCYB14. CXCL14 a une masse de 13.08kDa et une longueur d'acide aminé de 111.
Nous proposons 6 CXCL14 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Résumé Entrez
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
Spécificité tissulaire
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
Similitudes de séquence
Belongs to the intercrine alpha (chemokine CxC) family.
Modification post-traductionnelle
Ubiquitinated, followed by degradation by the proteasome.
Localisation cellulaire
Secreted.
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