CD99 est un gène codé par le symbole CD99. D'autres noms incluent: CD99 antigen; 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; MIC2; MIC2X; MIC2Y. CD99 a une masse de 18.85kDa et une longueur d'acide aminé de 185.
Nous proposons 4 CD99 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
Résumé Entrez
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus.
Similitudes de séquence
Belongs to the CD99 family.
Modification post-traductionnelle
Extensively O-glycosylated.
Localisation cellulaire
Membrane.
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