CD226 est un gène codé par le symbole CD226. D'autres noms incluent: CD226 antigen; DNAX accessory molecule 1; DNAM-1; DNAM1. CD226 a une masse de 38.61kDa et une longueur d'acide aminé de 336.
Nous proposons 4 CD226 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
Résumé Entrez
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Expressed by peripheral blood T-lymphocytes.
Localisation cellulaire
Cell membrane.
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