CCL28 est un gène codé par le symbole CCL28. D'autres noms incluent: C-C motif chemokine 28; Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28; SCYA28. CCL28 a une masse de 14.28kDa et une longueur d'acide aminé de 127.
Nous proposons 2 CCL28 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Résumé Entrez
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene.
Spécificité tissulaire
Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Localisation cellulaire
Secreted.
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