Betacellulin est un gène codé par le symbole BTC. Il est également connu sous le nom de ProBTC. Betacellulin a une masse de 19.75kDa et une longueur d'acide aminé de 178.
Nous proposons 6 Betacellulin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Résumé Entrez
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.
Spécificité tissulaire
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Localisation cellulaire
Secreted > Extracellular space.
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