beta Defensin 1 est un gène codé par le symbole DEFB1. D'autres noms incluent: Beta-defensin 1; BD-1; Defensin, beta 1; DEFB1; BD1; HBD1. beta Defensin 1 a une masse de 7.42kDa et une longueur d'acide aminé de 68.
Nous proposons 3 beta Defensin 1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Résumé Entrez
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Spécificité tissulaire
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Similitudes de séquence
Belongs to the beta-defensin family.
Localisation cellulaire
Secreted. Membrane.
Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).
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