BCMA est un gène codé par le symbole TNFRSF17. D'autres noms incluent: Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; TNFRSF17; BCM. BCMA a une masse de 20.17kDa et une longueur d'acide aminé de 184.
Nous proposons 13 BCMA protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Résumé Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Spécificité tissulaire
Expressed in mature B-cells, but not in T-cells or monocytes.
Localisation cellulaire
Cell membrane. Endomembrane system.
Perinuclear Golgi-like structures.
Liens de base de données
