BCA1 est un gène codé par le symbole CXCL13. D'autres noms incluent: C-X-C motif chemokine 13; Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; CXCL13; BLC; SCYB13. BCA1 a une masse de 12.66kDa et une longueur d'acide aminé de 109.
Nous proposons 4 BCA1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Résumé Entrez
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Spécificité tissulaire
Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.
Similitudes de séquence
Belongs to the intercrine alpha (chemokine CxC) family.
Localisation cellulaire
Secreted.
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