Zyxin est un gène codé par le symbole ZYX. Il est également connu sous le nom de: Zyxin-2; ZYX. Zyxin a une masse de 61.28kDa et une longueur d'acide aminé de 572.
Nous proposons 7 des anticorps contre Zyxin, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Résumé Entrez
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Similitudes de séquence
Belongs to the zyxin/ajuba family.
Localisation cellulaire
Cytoplasm. Cytoplasm > Cytoskeleton. Nucleus. Cell junction > Focal adhesion.
Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
